I've been down with ESET lately.. that and Defender.. crap.. I got my antivirus even off right now.. it's probably stupid but I guess I don't care and well.. to my knowledge I don't have any viruses.. er.. shutdown.. but seriously my antivirus isn't on now.. I probably should turn it on. ha..
actually, there is no antivirus program can save your computer 100%.
second, depend on what are you using computer for....
kaspersky, good choice but it is heavy,
also ( Eset Nod32 smart security ) good choice.